or in a thesis or dissertation provided that the correct acknowledgement is given
; Chen, C.F. Rattanangkool, E.; Kittikhunnatham, P.; Damsud, T.; Wacharasindhu, S.; Phuwapraisirisan, P. Quercitylcinnamates, a new series of antidiabetic bioconjugates possessing α-glucosidase inhibition and antioxidant. Needless to say, it is possible according to the invention to use cinnamic acid or its derivatives alone or as a mixture. CEMMPRE, Department of Chemical Engineering, University of Coimbra, 3030-790 Coimbra, Portugal
Caffeic and chlorogenic acids in. ; Zimmet, P.Z. And Cinnamic acid derivatives were prepared by the benzaldehyde derivatives and malonic acids. Adisakwattana, S.; Chantarasinlapin, P.; Thammarat, H.; Yibchok-Anun, S. A series of cinnamic acid derivatives and their inhibitory activity on intestinal alpha-glucosidase. Owing to these chemical aspects cinnamic acid derivatives received much attention in medicinal research as traditional as well … Scheen, A.J. ; Buse, J.B.; Diamant, M.; Ferrannini, E.; Nauck, M.; Peters, A.L. Adisakwattana, S.; Sompong, W.; Meeprom, A.; Ngamukote, S.; Yibchok-Anun, S. Cinnamic acid and its derivatives inhibit fructose-mediated protein glycation. Cinnamic acid and its derivatives (, As they occur widely and abundantly in human diets, several studies have provided evidence of daily consumption of cinnamic acid and its derivatives in worldwide populations. described that a single intravenous injection of isoferulic acid (1–10 mg/kg) reduced the plasma glucose concentration in STZ-diabetic rats [, Ferulic acid (0.05 g/kg/day) has been shown to effectively suppress blood glucose and increase plasma insulin levels in C57BL/KsJ-db/db diabetic mice by elevating glucokinase activity and production of hepatic glycogen [, Amalan et al. ; Chen, W.C.; Cheng, J.T. The concept of ‘substrate engineering’ as opposed to ‘enzyme engineering’, offers a complimentary and faster approach to developing a bioprocess, making difficult transformations possible. ; Tsapas, A.; Wender, R.; Matthews, D.R. RESULTS Initial Identiﬁcation of GLIC Ligands Using a Library of Gloeobacter violaceus Metabolites. firstname.lastname@example.org, b
SGLT2 inhibition: Efficacy and safety in type 2 diabetes treatment. ; Yousef, G.; de Mejia, E.G. Vague, P.; Coste, T.C. Mediation of beta-endorphin by isoferulic acid to lower plasma glucose in streptozotocin-induced diabetic rats. © 2017 by the authors. Aune, D.; Keum, N.; Giovannucci, E.; Fadnes, L.T. Endocrinol. PPAR gamma gene—A review. ; Amarowicz, R.; Swanson, R.B. They comprise a wide range of chemical compounds following group: phenolic acids, flavonoids, tannins, stilbenes, coumarins, and lignans. ; Lee, M.K. Role of peroxisome proliferator-activated receptor-gamma in the glucose-sensing apparatus of liver and beta-cells. Cinnamic acid derivatives, especially those combining the cinnamoyl moiety with hydroxyl groups, present strong free radical scavenging properties. Cinnamic acid (CA) and its hydroxy-derivatives are aromatic building blocks whose structural peculiarities (unsaturation, hydroxylic and/or carboxylic groups) have driven them to a prominent position in polymer science.
; Hamaker, B.R. Adiponectin signaling and function in insulin target tissues. ; López-Rubio, A. There is also one salt. Sompong, W.; Cheng, H.; Adisakwattana, S. Ferulic acid prevents methylglyoxal-induced protein glycation, DNA damage, and apoptosis in pancreatic β-cells. ; Vimalambike, M.G. The antioxidant activity was measured using (i) a competition kinetic test, to measure the relative capacity to quench … Li, W.; Zhao, X.; Sun, X.; Zu, Y.; Liu, Y.; Ge, Y. This may take some time to load. Go to our
Hafizur, R.M. Grosso, G.; Stepaniak, U.; Topor-Mądry, R.; Szafraniec, K.; Pająk, A. Kopp, C.; Singh, S.P. Narita, Y.; Inouye, K. Kinetic analysis and mechanism on the inhibition of chlorogenic acid and its components against porcine pancreas α-amylase isozymes I and II. Crepaldi, G.; Carruba, M.; Comaschi, M.; Del Prato, S.; Frajese, G.; Paolisso, G. Dipeptidyl peptidase 4 (DPP-4) inhibitors and their role in Type 2 diabetes management. Inhibition of the protein in tyrosine phosphatase PTP1B: Potential therapy for obesity, insulin resistance and type-2 diabetes mellitus. Bioavailability of hydroxycinnamates: A brief review of in vivo and in vitro studies. Licensee MDPI, Basel, Switzerland. ; Prasad, R.; Ali, S.; Doble, M. Synergistic interaction of ferulic acid with commercial hypoglycemic drugs in streptozotocin induced diabetic rats. ; Verpoorte, R. Biosynthesis, natural sources, dietary intake, pharmacokinetic properties, and biological activities of hydroxycinnamic acids. ; Riboli, E.; Norat, T. Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: Systematic review and dose-response meta-analysis of prospective studies. Giacco, R.; Costabile, G.; Pepa, G.D.; Anniballi, G.; Griffo, E.; Mangione, A.; Cipriano, P.; Viscovo, D.; Clemente, G.; Landberg, R.; et al. Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells. Currently, there are six distinct classes of available hypoglycemic agents: sulfonylureas, meglitinides, biguanides, thiazolidinediones, α-glucosidase inhibitors, and dipeptidyl peptidase-IV (DPP-IV) inhibitors [, Polyphenols are one of the most important and abundant phytochemical compounds in human diets. ; Yoo, N.H.; Lee, Y.M. Insulin resistance and adipogenesis: Role of transcription and secreted factors. Cinnamic acid is an organic acid occurring naturally in plants that has low toxicity and a broad spectrum of biological activities. Molecular mediators of hepatic steatosis and liver injury. Kimura, A. Molecular anatomy of α-glucosidase. Ohara, K.; Uchida, A.; Nagasaka, R.; Ushio, H.; Ohshima, T. The effects of hydroxycinnamic acid derivatives on adiponectin secretion. ; Marin, D.; Puigpinos, A.; Mendieta, L.; Tarragó, T.; Morel, A.F. Philippe, J.; Raccah, D. Treating type 2 diabetes: How safe are current therapeutic agents? An overview on the role of dietary phenolics for the treatment of cancers. ; Liu, I.M. ; Tkachuk, V.A. Wang, F.; Hull, R.L. ; Wei, X.; Qi, F.M. Cinnamic acid, from the bark of. If you are the author of this article you do not need to formally request permission
The aim of the review is to summarize the potential mechanisms of these compounds for prevention and management of diabetes and its complications. Koren, S.; Fantus, I.G. ; Sultan, M.T. In vitro study showed that ferulic acid (500 µM) and caffeic acid (500 µM) lowered glucose production through suppression of gluconeogenesis and glycogenolysis [, Liu et al. Johnston, K.; Sharp, P.; Clifford, M.; Morgan, L. Dietary polyphenols decrease glucose uptake by human intestinal Caco-2 cells. If you are the author of this article you still need to obtain permission to reproduce
Mapping the intestinal alpha-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase. ; Yibchok-anun, S. Mechanisms of antihyperglycemic effect of p-methoxycinnamic acid in normal and streptozotocin-induced diabetic rats. Coffee and its consumption: Benefits and risks. Oxidative damage of DNA induced by methylglyoxal in vitro. Several cinnamic acid derivatives have been reported to exhibit antiviral activity. ; Choi, M.S. The antioxidant activity of four derivatives of benzoic acid was systematically compared with the activity of the four homologous derivatives of cinnamic acid. Cookies help us deliver our services. Effect of youth-onset type 2 diabetes mellitus on incidence of end-stage renal disease and mortality in young and middle-aged Pima Indians. ; Jeon, S.M. Authors contributing to RSC publications (journal articles, books or book chapters)
Simsek, M.; Quezada-Calvillo, R.; Ferruzzi, M.G. ; Boffetta, P.; Greenwood, D.C.; Tonstad, S.; Vatten, L.J.
Sompong, W.; Cheng, H.; Adisakwattana, S. Protective effects of ferulic acid on high glucose-induced protein glycation, lipid peroxidation, and membrane ion pump activity in human erythrocytes. Effects of caffeic acid and cinnamic acid on glucose uptake in insulin-resistant mouse hepatocytes. Zhang, Y.; Li, Z.; Zhang, K.; Yang, G.; Wang, Z.; Zhao, J.; Hu, R.; Feng, N. Ethyl oleate-containing nanostructured lipid carriers improve oral bioavailability of trans-ferulic acid ascompared with conventional solid lipid nanoparticles.
; Hsu, F.L. Effects of flavonoids and phenolic acids on the inhibition of adipogenesis in 3T3-L1 adipocytes. Today we make some Trans-cinnamic acid from benzaldehyde and malonic acid. Stimulatory effect of isoferulic acid on alpha1A-adrenoceptor to increase glucose uptake into cultured myoblast C2C12 cell of mice. Improved antioxidant capacity of quercetin and ferulic acid during in vitro digestion through encapsulation within food-grade electrospun fibers. Indeed, CA hydroxy-derivatives (hydroxycinnamic acids, HCAs) have been extensively used in the preparation of polyesters, but there are also reports about their use in the synthesis of polyamides and poly(anhydride esters), among many other uses. Kim, H.I. This lecture describes biosynthesis of cinnamic acid and its derivatives from phenylalanine and tyrosine. De Cássia da Silveira e Sá, R.; Andrade, L.N. is available on our Permission Requests page. Cinnamic acid (CA) and its hydroxy-derivatives are aromatic building blocks whose structural peculiarities (unsaturation, hydroxylic and/or carboxylic groups) have driven them to a prominent position in polymer science. Separation and characterization of soluble esterified and glycoside-bound phenolic compounds in dry-blanched peanut skins by liquid chromatography-electrospray ionization mass spectrometry. Luo, L.; Liu, M. Adipose tissue in control of metabolism. ; Chen, G.T. XX is the XXth reference in the list of references. The prevalence of type 2 diabetes mellitus has increased dramatically in epidemic proportions worldwide that is one of the most important health and socioeconomic problems [, Current anti-diabetic drugs are commonly required for treatment of type 2 diabetes aimed to achieve glycemic control and relieve diabetic symptoms. Based on several in vitro studies and animal models, cinnamic acid and its derivatives act on different mechanism of actions, including stimulation of insulin secretion, improvement of pancreatic β-cell functionality, inhibition of hepatic gluconeogenesis, enhanced glucose uptake, increased insulin signaling pathway, delay of carbohydrate digestion and glucose absorption, and inhibition of protein glycation and insulin fibrillation. Tahrani, A.A.; Barnett, A.H.; Bailey, C.J. Corresponding authors, a
The structure was confirmed by MS and 1H NMR. Its biosynthesis involves the action of the enzyme phenylalanine ammonia-lyase (PAL) on phenylalanine. ; Adisakwattana, S. Isoferulic acid prevents methylglyoxal-induced protein glycation and DNA damage by free radical scavenging activity. Maruf, A.A.; Lip, H.; Wong, H.; O’Brien, P.J. Jairajpuri, D.S. Guo, S. Insulin signaling, resistance, and the metabolic syndrome: Insights from mouse models into disease mechanisms. ; Bergenstal, R.M. ; Narayanan, R.B. Tailleux, A.; Wouters, K.; Staels, B. These new matrices (sinapic, ferulic and caffeic acids) are cinnamic acid derivatives that have several pratical advantages over the nicotinic acid matrices previously used. ; Xu, L.J. In the category of phytochemicals that can be found in food, there are : α-Cyano-4-hydroxycinnamic acid Caffeic acid – burdock, hawthorn, artichoke, pear, basil, thyme, oregano, apple ; Lila, M.A. Panzhinskiy, E.; Ren, J.; Nair, S. Pharmacological inhibition of protein tyrosine phosphatase 1B: A promising strategy for the treatment of obesity and type 2 diabetes mellitus. Smith, P.R. ; Yue, Q.X. Prabhakar, P.K. Isoferulic acid action against glycation-induced changes in structural and functional attributes of human high-density lipoprotein. Res. SGLT inhibitors in management of diabetes. Cinnamic acid derivatives are widely used in cosmetics and possess various functions. Guzman, J.D. If you are not the author of this article and you wish to reproduce material from